A peptide similar to AMP, AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), is also known as ZMP. It is a naturally occurring chemical believed to activate AMP-dependent kinase, an enzyme that is considered to control metabolic rate. Researchers may also produce the AMPK-stimulating AICAR in the lab for testing reasons. Scientists are now doing preclinical studies and mouse trials to investigate the research potential of AICAR in the context of several metabolic illnesses.The AICAR Peptide: What Is It? Studies have suggested that the AICAR peptide hormone may potentially impact the cardiovascular system and combat cancer cells. Another function it is believed to have is to stop blood blood clotting. Because of this, researchers are eager to keep digging into this protein.In the 1980s, researchers researched AICAR in relation to blood flow. According to researchers, the peptide AICAR may be relevant in diabetes research because it may potentially increase the metabolic capabilities of tissues by influencing the organism’s muscular composition.AICAR Peptide OverviewAccording to clinical trials, AICAR seems to increase the organism’s energy availability. Cells may manufacture more mitochondria, which are believed responsible for converting fat into energy, and the utilization of fat cells for energy is increased. The AICAR peptide is believed to keep the organism’s tissues from becoming exhausted.Researchers speculated that AICAR-exposed mice appeared to have improved running speed by 44% without further training. Findings imply that AICAR may be engaged in various metabolic processes.AICAR Peptide and Muscle Cells Scientists speculate that gaining muscle mass may be one of the actions of AICAR. It is considered an essential protein to increase muscle development and maintain muscular mass. Furthermore, research has indicated that it may help slow the natural decline in muscle mass accompanying the process of cell cycles.A McMaster University research reported that AMPK may play a critical role in preventing the natural loss of muscle mass. Scientists were surprised by the extent of muscular weakening observed in mice missing this protein. These results suggest that the AICAR peptide may have promise as a future approach for disorders associated with muscular atrophy.
AICAR Peptide and InflammationNew data from experimental studies points to AICAR’s possible function in cellular inflammation. In inflammatory diseases such as atherosclerosis, hepatitis, asthma, and colitis, AICAR is hypothesized to act as a protector. It has been theorized that ACIAR may potentially reduce inflammation in colitis. According to researchers, AICAR also seems to mediate the action of inflammatory disorders and autoimmune illnesses.Sperm motility, metabolism, and fertilization capacity may potentially be improved by AMPK activators like AICAR, as suggested by research in cats, chickens, and goats.AICAR Peptide and Insulin SensitivityStudies conducted on mice have suggested that high and low AICAR concentrations may reduce inflammation in adipose tissue, the connective tissue responsible for storing energy as fat.Inflammation in fat is linked to increased insulin resistance. Better glucose homeostasis results from lowering that inflammation. AICAR is believed to affect adipose tissue inflammation via many mechanisms, including SIRT1 and macrophages.In another study, obese monkeys appeared to have lost weight and had better insulin resistance. Further AICAR investigations purported that metabolic diseases seemed to have diminished the inflammatory response in control and diabetic mice alike. In addition to enhancing insulin sensitivity, AICAR has been speculated to enhance lipid metabolism, energy balance, and inflammatory symptoms in studies.AICAR Peptide and the HeartAICAR Peptide and Fertility To maximize AICAR’s efficacy, researchers are looking into evaluate it alongside other chemotherapeutic substances. According to their estimation, AICAR may potentially act in the following regards: Cut down on unwanted consequences.
Enhance the prognosis for tumor-free mice.Researchers have hypothesized that AICAR may potentially induce p21 accumulation, which leads to programmed cell death in thyroid cancer cells. Scientists speculate that AICAR may reduce cancer cells’ ability to multiply and survive.Scientists interested in AICAR or other high-quality, affordable research compounds are encouraged to visit the Core Peptides website.References[i] Yang, Hong, Lingling Zhao, Douglas Stevenson, Mark Bartlett, and Bin Lou. “Anti-Inflammatory Effect of AMPK Activators from Natural Products in RAW 264.7 Cell Model (P06-095-19).” Current Developments in Nutrition 3, no. Supplement_1 (June 1, 2019). doi:10.1093/cdn/nzz031.p06-095-19. [ii] Criscione, L. “Comment on ‘A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys.’” Science Translational Medicine 4, no. 131 (April 25, 2012): 131le2–131le2. doi:10.1126/scitranslmed.3003760.[iii] Spurr, Ian B., Charles N. Birts, Francesco Cuda, Stephen J. Benkovic, Jeremy P. Blaydes, and Ali Tavassoli. “Targeting Tumour Proliferation with a Small-Molecule Inhibitor of AICAR Transformylase Homodimerization.” ChemBioChem 13, no. 11 (July 4, 2012): 1628–1634. doi:10.1002/cbic.201200279.[iv] Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. Br J Cancer. 2023 May;128(9):1647-1664. doi: 10.1038/s41416-023-02196-z. Epub 2023. PMID: 36810913; PMCID: PMC10133251.[v] Zineldeen DH, Tahoon NM, Sarhan NI. AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic Reticular Impairments in High-Fat Diet-Fed Rats. Int J Mol Sci. 2023 Feb 8;24(4):3367. doi: 10.3390/ijms24043367. PMID: 36834782; PMCID: PMC9959470.